Clinical trials

Amarasate is undergoing clinical trials to build scientific evidence to support its activity

Amarasate® reduces hunger during fasting

Fasting offers numerous health benefits for some people -replicating some of the benefits of calorie restriction and is associated with improvements in metabolic and cardiovascular health. However compliance to fasting is often difficult due to hunger during the late stages of the fast.

In this trial we assessed the effect of Amarasate™ on hunger during a 24hour water-only fast. The results showed that Amarasate™ reduced feelings of hunger during the fasting period, including the absence of an increase in hunger at lunchtime.

The results of this trial was published in Nutrients (2019).

Amarasate™ stimulates the Bitter Brake on appetite and reduces food intake

Bitter plants have been used by many cultures as traditional medicines to regulate appetite and to enhance health. These benefits are thought to act via signals that come from the gut when it is exposure to exceedingly bitter compounds, a mechanism we call the 'bitter brake'.

In this trial we wanted to see if Amarasate™ could activate the bitter brake and effect how much food participants ate. The results showed that Amarasate™ was a potent activator of the bitter brake satiety mechanisms and reduced the amount of food participants wanted to each by approximately 20%.

This trial has been completed and results will be published shortly.

Amarasate™ for extending fullness

We have shown that Amarasate™ can trigger the bitter brake satiety signal, making people eat less when taken before a buffet meal and feel less hungry during fasting. In this study we wanted to know if Amarasate™ could prolong the feeling of fullness you get from eating a fixed sized meal.

This trial has been completed and the data is currently undergoing analysis prior to publication.

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